PMID- 32293773 OWN - NLM STAT- Publisher LR - 20200415 IS - 1369-1600 (Electronic) IS - 1355-6215 (Linking) DP - 2020 Apr 15 TI - Biomarkers of endothelial dysfunction in cocaine overdose and overdose-related cardiovascular events. PG - e12901 LID - 10.1111/adb.12901 [doi] AB - Overdose of stimulant drugs has been associated with increased risk of adverse cardiovascular events (ACVE), some of which may be ascribed to endothelial dysfunction. The aims of this study were to evaluate biomarkers of endothelial dysfunction in emergency department (ED) patients with acute cocaine overdose and to assess the association between in-hospital ACVE in ED patients with any acute drug overdose. This was a prospective consecutive cohort study over 9 months (2015-2016) at two urban, tertiary-care hospital EDs. Consecutive adults (>/=18 years) presenting with suspected acute drug overdose were eligible and separated into three groups: cocaine (n = 47), other drugs (n = 128), and controls (n = 11). Data were obtained from medical records and linked to waste serum specimens, sent as part of routine clinical care, for biomarker analysis. Serum specimens were collected and analyzed using enzyme-linked immunosorbent assay kit for three biomarkers of endothelial dysfunction: (a) endothelin-1 (ET-1), (b) regulated upon activation normal T cell expressed and secreted (RANTES), and (c) soluble intercellular adhesion molecule-1 (siCAM-1). Mean siCAM was elevated for cocaine compared with controls and other drugs (p < .01); however, mean RANTES and ET-1 levels were not significantly different for any drug exposure groups. Receiver operating characteristics curve analysis for prediction of in-hospital ACVE revealed excellent performance of siCAM-1 (area under curve, 0.86; p < .001) but lack of predictive utility for either RANTES or ET-1. These results suggest that serum siCAM-1 is a viable biomarker for acute cocaine overdose and that endothelial dysfunction may be an important surrogate for adverse cardiovascular events following any drug overdose. CI - (c) 2020 Society for the Study of Addiction. FAU - Manini, Alex F AU - Manini AF AUID- ORCID: https://orcid.org/0000-0001-8276-9320 AD - Division of Medical Toxicology, Department of Emergency Medicine, The Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, New York, New York, USA. FAU - Gibson, Claire L AU - Gibson CL AD - Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Miller, Michael L AU - Miller ML AUID- ORCID: https://orcid.org/0000-0002-6350-5706 AD - Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Richardson, Lynne D AU - Richardson LD AD - Department of Emergency Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Vargas-Torres, Carmen C AU - Vargas-Torres CC AD - Department of Emergency Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Vedanthan, Rajesh AU - Vedanthan R AD - Department of Population Health, NYU Langone School of Medicine, New York, New York, USA. FAU - Hurd, Yasmin L AU - Hurd YL AD - Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. LA - eng GR - DA/NIDA NIH HHS/United States GR - DA037317-02S2/NH/NIH HHS/United States PT - Journal Article DEP - 20200415 PL - United States TA - Addict Biol JT - Addiction biology JID - 9604935 SB - IM OTO - NOTNLM OT - acute drug overdose OT - biomarker OT - cardiovascular events OT - cocaine OT - endothelial dysfunction EDAT- 2020/04/16 06:00 MHDA- 2020/04/16 06:00 CRDT- 2020/04/16 06:00 PHST- 2019/11/08 00:00 [received] PHST- 2020/03/05 00:00 [revised] PHST- 2020/03/13 00:00 [accepted] PHST- 2020/04/16 06:00 [entrez] PHST- 2020/04/16 06:00 [pubmed] PHST- 2020/04/16 06:00 [medline] AID - 10.1111/adb.12901 [doi] PST - aheadofprint SO - Addict Biol. 2020 Apr 15:e12901. doi: 10.1111/adb.12901.